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Development and Spread of Cancer

By

Robert Peter Gale

, MD, PhD, DSC(hc), Imperial College London

Medically Reviewed Oct 2022
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Malignant transformation is the complex process by which cancerous cells develop from healthy cells. It consists of several steps:

  • Initiation

  • Promotion

  • Spread

Initiation

The first step in cancer development is initiation, in which a change in a cell’s genetic material (a mutation) primes the cell to become cancerous. The change in the cell’s genetic material may occur spontaneously as a random event or due to a gene mutation or be brought on by an external exposure to a substance that causes cancer (a carcinogen).

Carcinogens Some Carcinogens Some Carcinogens include many chemicals, tobacco, viruses, radiation, and sunlight. However, not all cells are equally susceptible to carcinogens. And not all people exposed to a carcinogen will develop cancer. The risk depends on many factors, for example, the amount of exposure the person had to that carcinogen or whether the person has a genetic predisposition to a certain type of cancer.

Promotion

The second and final step in the development of cancer is promotion. Agents that cause promotion, or promoters, may be substances in the environment or even some medications, such as sex hormones (for example, testosterone taken to improve sex drive and energy in older men). Unlike carcinogens, promoters do not cause cancer by themselves. Instead, promoters allow a cell that has undergone initiation to become cancerous. Promotion has no effect on cells that have not undergone initiation.

Some carcinogens are sufficiently powerful to be able to cause cancer without the need for promotion. For example, ionizing radiation Radiation Injury Radiation injury is damage to tissues caused by exposure to ionizing radiation. Large doses of ionizing radiation can cause acute illness by reducing the production of blood cells and damaging... read more (which is used in x-rays and is produced in nuclear power plants and atomic bomb explosions) can cause various cancers, particularly sarcomas, leukemia, thyroid cancer, and breast cancer.

Spread

Cancer can grow directly into (invade) surrounding tissue or spread to tissues or organs, nearby or distant. Cancer can spread through the lymphatic system Overview of the Lymphatic System The lymphatic system is a vital part of the immune system. It includes organs such as the thymus, bone marrow, spleen, tonsils, appendix, and Peyer patches in the small intestine that produce... read more . This type of spread is typical of carcinomas. For example, breast cancer usually spreads first to the nearby lymph nodes in the armpit, and only later does it spread to distant sites. Cancer can also spread via the bloodstream. This type of spread is typical of sarcomas.

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