MSD Manual

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Birendra P. Sah

, MD, FCCP, Upstate Medical University

Reviewed/Revised Apr 2023
Topic Resources

Sarcoidosis is a disease in which abnormal collections of inflammatory cells (granulomas) form in many organs of the body.

  • Sarcoidosis usually develops in people aged 20 to 40 years, most often people of European or African ancestry.

  • It can affect many organs, most commonly the lungs.

  • People typically cough and have difficulty breathing but can have various symptoms, depending on which organs are affected.

  • Diagnosis usually requires chest x-ray, computed tomography (CT), and analysis of a sample of tissue (biopsy), usually from the lungs.

  • Symptoms eventually subside without treatment in most people.

  • Treatment, when necessary, begins with corticosteroids.

The cause of sarcoidosis is unknown. It may result from an abnormal response of the immune system to a substance encountered in the environment, such as mold or mildew or to certain bacteria. Inherited genetic factors seem to play a role as well. Sarcoidosis typically develops between the ages of 20 and 40 years. It is most common among people of European ancestry and Americans of African ancestry, although it can occur in anyone.

Sarcoidosis is characterized by the presence of collections of inflammatory cells (granulomas). The disease is primarily one of the lungs and lymph nodes, but granulomas can also form in any organ, including the liver, eyes, and skin, and less often the spleen, bones, joints, sinuses, skeletal muscles, kidneys, heart, reproductive organs, salivary glands, and nervous system. The granulomas may eventually disappear completely or become scar tissue.

Sarcoidosis may manifest as certain syndromes.

Löfgren syndrome

Löfgren syndrome manifests as three specific symptoms: acute inflammation of several joints (arthritis) and may affect different joints at different times, tender red bumps under the skin (erythema nodosum Erythema Nodosum Erythema nodosum is a form of panniculitis (inflammation of the fat layer beneath the skin) that produces tender red or violet bumps (nodules) under the skin, most often over the shins but occasionally... read more Erythema Nodosum ), and enlargement of the lymph nodes in the area where the lungs are connected to the heart and the windpipe. It often causes fever and malaise, inflammation of the lining of the eye (uveitis Uveitis Uveitis is inflammation anywhere in the pigmented inside lining of the eye, known as the uvea or uveal tract. The uveal tract may become inflamed because of infection, injury, a bodywide autoimmune... read more ), and sometimes inflammation of the parotid glands (the pair of salivary glands that lie just behind the angle of the jaw, below and in front of the ears). It is more common among women of European, particularly Scandinavian, descent.

Löfgren syndrome often resolves on its own. But people may be given nonsteroidal anti-inflammatory drugs to help relieve symptoms and inflammation.

Heerfordt syndrome

Heerfordt syndrome (also called uveoparotid fever) manifests as swelling of the parotid glands (due to infiltration with inflammatory cells), inflammation of the eye (uveitis Uveitis Uveitis is inflammation anywhere in the pigmented inside lining of the eye, known as the uvea or uveal tract. The uveal tract may become inflamed because of infection, injury, a bodywide autoimmune... read more ), chronic fever, and less often weakness or paralysis of the facial nerve. Heerfordt syndrome can resolve on its own. Treatment is the same as for sarcoidosis and includes nonsteroidal anti-inflammatory drugs, including corticosteroids.

Blau syndrome

Blau syndrome, a sarcoidosis-like disorder, is inherited in an autosomal dominant manner. In Blau syndrome, symptoms develop before the age of 4 years. Symptoms typically include arthritis, rash, and uveitis.

Symptoms of Sarcoidosis

Many people with sarcoidosis have no symptoms, and the disorder is discovered on a chest x-ray that is taken for other reasons. Most people develop minor symptoms that do not progress.

The symptoms of sarcoidosis vary greatly according to the site and extent of the disease as well as by the age and sex of the person affected.


Fever, fatigue, vague chest pain, a feeling of illness (malaise), loss of appetite, weight loss, and aching joints may be the first indications of a problem in about one third of people. Enlarged lymph nodes are common but do not often cause symptoms. Fever and night sweats may recur throughout the illness.


The organs most affected by sarcoidosis are the lungs. Enlarged lymph nodes at the place where the lungs meet the heart or next to the sides of the windpipe (trachea) may be seen on a chest x-ray. Sarcoidosis causes inflammation in the lungs that may eventually lead to scarring and the formation of cysts. Fortunately, such progressive scarring occurs infrequently. Occasionally, the fungus Aspergillus can settle in (colonize) the lung cysts, grow, and cause bleeding. Breathing can become difficult. Severe involvement of the lung by sarcoidosis can eventually strain the right side of the heart, causing right-sided heart failure (cor pulmonale Cor Pulmonale Cor pulmonale is enlargement and thickening of the ventricle on the right side of the heart resulting from an underlying lung disorder that causes pulmonary hypertension (high pressures in the... read more ).


The skin is frequently affected by sarcoidosis. Sarcoidosis often starts as a rash with raised, tender, red lumps, usually on the shins (erythema nodosum Erythema Nodosum Erythema nodosum is a form of panniculitis (inflammation of the fat layer beneath the skin) that produces tender red or violet bumps (nodules) under the skin, most often over the shins but occasionally... read more Erythema Nodosum ), often accompanied by a fever and joint pain. The rash tends to resolve within 3 to 6 months but may recur. It is less common in Black Americans of African descent. Common skin lesions in sarcoidosis include little bumps (called papules) and larger bumps (called nodules). Prolonged sarcoidosis may lead to the formation of flat patches, raised patches (plaques), or plaques that discolor the nose, cheeks, lips, and ears (lupus pernio). Skin patches may be darker or lighter than surrounding skin. Lupus pernio is most common in Black people. People with lupus pernio may also develop granulomas in the nasal passage that cause symptoms similar to those of sinusitis Sinusitis Sinusitis is inflammation of the sinuses, most commonly caused by a viral or bacterial infection or by an allergy. Some of the most common symptoms of sinusitis are pain, tenderness, nasal congestion... read more .

Manifestations of Sarcoidosis

Liver and spleen

Up to 75% of people with sarcoidosis have granulomas in their liver. These granulomas often cause no symptoms, and the liver seems to function normally. However, blood tests may show evidence of liver involvement even when symptoms of it are absent. Fewer than 10% of people with sarcoidosis have an enlarged liver. Yellow coloring of the skin and whites of the eyes (jaundice) caused by liver malfunction is rare.

The spleen also is enlarged in some people. When the spleen is enlarged, people may have pain in the upper part of the abdomen.


The eyes are affected in 25% of people with sarcoidosis, particularly Americans of African descent and people of Japanese descent. Uveitis Uveitis Uveitis is inflammation anywhere in the pigmented inside lining of the eye, known as the uvea or uveal tract. The uveal tract may become inflamed because of infection, injury, a bodywide autoimmune... read more makes the eyes red and painful and interferes with vision. Inflammation that persists for a long time may block fluid from draining from the eye, causing glaucoma Glaucoma Glaucomas are a group of eye disorders characterized by progressive optic nerve damage (often, but not always, associated with increased eye pressure) that can lead to irreversible loss of vision... read more , which can lead to blindness. Granulomas may form in the membrane over the eyeball and inside the eyelids (conjunctiva). Such granulomas often do not cause symptoms, but the conjunctiva is an accessible site from which doctors can take tissue samples for examination. Some people with sarcoidosis complain of dry, sore, and red eyes, probably because tear glands that have been affected by the disorder no longer produce enough tears to keep the eyes lubricated.


Joints, muscles, and bones

Inflammation can cause widespread pain in the joints. The joints in the wrists, elbows, knees, and ankles are most commonly affected. Cysts form in the bones and can make nearby joints swollen and tender. Sometimes people also have muscle weakness.

Nervous system

Sarcoidosis can affect the cranial nerves (nerves of the head), causing double vision or hearing loss, or making one side of the face droop. If the pituitary gland or the bones surrounding it are affected, arginine vasopressin deficiency ArginineVasopressin Deficiency (Central Diabetes Insipidus) Argininevasopressin deficiency (central diabetes insipidus) is a lack of the hormone vasopressin (antidiuretic hormone) that causes excessive production of very dilute urine (polyuria). Argininevasopressin... read more (central diabetes insipidus) may result. In argininevasopressin deficiency, the pituitary gland stops producing vasopressin, a hormone needed by the kidneys to concentrate urine, causing excessive production of urine.

High calcium levels

Diagnosis of Sarcoidosis

  • Chest imaging

  • Biopsy

Doctors most often suspect sarcoidosis when they observe its distinctive changes, including enlarged lymph nodes and abnormal findings on a chest x-ray or on computed tomography (CT).

Further testing is necessary, typically microscopic examination of a tissue sample (biopsy) from the affected organ showing inflammation and granulomas, to confirm the diagnosis. Bronchoscopy with ultrasound-guided needle biopsy is 90% accurate and is the preferred procedure for people whose lungs are involved. Other possible sources of tissue specimens are skin abnormalities, enlarged lymph nodes close to the skin, and granulomas on the conjunctiva. A liver biopsy is generally not done because liver granulomas can be caused by other disorders and so the biopsy may not provide a definite diagnosis. Cardiac magnetic resonance imaging (MRI), brain or spine MRI, bone scans, and electromyography may be done in people with symptoms related to those organ systems.

Tuberculosis Tuberculosis (TB) Tuberculosis is a chronic contagious infection caused by the airborne bacteria Mycobacterium tuberculosis. It usually affects the lungs, but almost any organ can be involved. Tuberculosis... read more Tuberculosis (TB) can cause many changes similar to those caused by sarcoidosis. Therefore, doctors also do a tuberculin skin test (and sometimes a lung biopsy) to help determine whether the problem is tuberculosis or sarcoidosis.

Other methods that can help doctors diagnose sarcoidosis or assess its severity include irrigating the lungs (bronchoalveolar lavage Procedures Done With Bronchoscopy Bronchoscopy is a direct visual examination of the voice box (larynx) and airways through a viewing tube (a bronchoscope). A bronchoscope, a thin viewing tube with a light, has a camera at the... read more Procedures Done With Bronchoscopy ) and examining the fluid. The fluid from a lung with active sarcoidosis contains a large number of lymphocytes White Blood Cells The main components of blood include Plasma Red blood cells White blood cells Platelets read more White Blood Cells , but this finding is not unique to sarcoidosis. Another test that is occasionally used is positron emission tomography (PET) scanning, which can detect even small areas of sarcoidosis that affects parts of the body other than the lungs.

In people with lung scarring, pulmonary function tests Pulmonary Function Testing (PFT) Pulmonary function tests measure the lungs' capacity to hold air, to move air in and out, and to absorb oxygen. Pulmonary function tests are better at detecting the general type and severity... read more Pulmonary Function Testing (PFT) may show that the amount of air the lungs can hold is below normal. A 6-minute walk test may be done to help determine how severely the lungs are affected. Blood tests may reveal a low number of white blood cells, red blood cells, or, rarely, platelets. Immunoglobulin levels are often high, especially in Black people. Levels of calcium in the blood or urine may be high. The levels of liver enzymes, particularly alkaline phosphatase, may be high if the liver is affected.

Treatment of Sarcoidosis

  • Nonsteroidal anti-inflammatory drugs

  • Corticosteroids

  • Drugs to suppress the immune system

Most people with sarcoidosis do not need treatment.

People may be given nonsteroidal anti-inflammatory drugs to relieve symptoms such as pain or fever.

Corticosteroids are given to suppress sarcoidosis that causes symptoms such as shortness of breath, joint or chest pain, and fever. These drugs also are given if

  • Tests show high levels of calcium in the blood, even if symptoms are mild.

  • Function of the heart, liver, or nervous system is affected.

  • Sarcoidosis causes disfiguring skin lesions or eye disease that corticosteroid eye drops do not cure.

  • Lung disease worsens.

Corticosteroids tend to temporarily slow tissue damage caused by sarcoidosis and control symptoms well, but they may not prevent lung scarring over the years. Corticosteroids also may help people with high levels of calcium in the blood or urine.

Sometimes other drugs that suppress the immune system are given if corticosteroids are ineffective or cause troublesome side effects. These drugs may include methotrexate, azathioprine, mycophenolate, cyclophosphamide, hydroxychloroquine, and leflunomide.

Hydroxychloroquine is sometimes helpful in treating disfiguring skin lesions, high blood calcium levels, and some enlarged, uncomfortable or disfiguring lymph nodes.

Some people, especially those in whom corticosteroids and another drug that suppresses the immune system have been ineffective, are treated with infliximab. For people who were treated successfully with infliximab but can no longer take infliximab because of its side effects, doctors can give adalimumab.

If the heart is involved, people may need an implantable cardiac defibrillator and a pacemaker.

Sometimes, transplantation of lungs, heart, or liver is done if sarcoidosis has severely affected these organs, but sarcoidosis can recur in the transplanted organ.

The success of treatment can be monitored with chest x-rays, CT, pulmonary function tests, and measurements of calcium in the blood. These tests are repeated regularly to detect relapses after treatment stops.

Moderate or severe lung damage increases the risk of death in people who have sarcoidosis and COVID-19. People with lung damage thus should be vaccinated against COVID-19 COVID-19 Vaccine Coronavirus disease 2019 (COVID-19) vaccines provide protection against COVID-19. COVID-19 is the disease caused by infection with the SARS-CoV-2 virus. There are multiple COVID-19 vaccines... read more . Doctors must sometimes withhold drugs that suppress the immune system in these people.

Prognosis for Sarcoidosis

Sarcoidosis improves or clears up spontaneously in nearly two thirds of people with lung sarcoidosis. Even enlarged lymph nodes in the chest and extensive lung inflammation may disappear in a few months or years. However, the course can be chronic or progressive in up to 30% of people. Serious involvement outside of the chest (for example, of the heart, nervous system, eyes, or liver) occurs in 4 to 7% of people at the beginning of their illness.

People with enlarged lymph nodes in the chest but no sign of lung disease have a very good prognosis. People with Löfgren syndrome often have the best prognosis. About 50% of people who once had sarcoidosis have relapses.

About 10 to 20% of people with sarcoidosis develop a serious disability due to damage to the eyes, respiratory system, or elsewhere. Sarcoidosis is fatal in 1 to 5% of affected people. Lung scarring leading to respiratory failure and cor pulmonale is the most common cause of death, followed by bleeding due to lung infection caused by Aspergillus.

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