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Overview of Spondyloarthritis

By

Kinanah Yaseen

, MD, Cleveland Clinic

Medically Reviewed Dec 2022
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Spondyloarthritis (also called spondyloarthropathy or spondyloarthritides) is a term used to describe a group of diseases that cause prominent joint inflammation, affect the spine and other joints, and share certain other characteristics. For example, they may cause back pain, inflammation of the eye (uveitis Uveitis Uveitis is inflammation anywhere in the pigmented inside lining of the eye, known as the uvea or uveal tract. The uveal tract may become inflamed because of infection, injury, a bodywide autoimmune... read more ), digestive symptoms, and rashes. Some are strongly associated with the HLA-B27 gene. Because they cause many of the same problems and share genetic characteristics, some experts think these disorders share similar causes and ways of causing symptoms.

Spondyloarthritis causes joint inflammation, similar to rheumatoid arthritis Rheumatoid Arthritis (RA) Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more Rheumatoid Arthritis (RA) . However, in contrast to rheumatoid arthritis, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) (see Blood tests Blood tests Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more Blood tests ) are usually negative in spondyloarthritis (hence, these disorders are also called the seronegative spondyloarthropathies). These disorders include

Juvenile-onset spondyloarthritis affects the lower extremities, often affects joints on opposite sides of the body to different degrees, and begins most commonly in boys aged 7 to 16.

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