Conditions That Occur With Certain Multiple Endocrine Neoplasia Syndromes
Condition | MEN 1 | MEN 2A | MEN 2B | MEN 4 |
|---|---|---|---|---|
Hyperparathyroidism (high levels of parathyroid hormone)(high levels of parathyroid hormone) | 95% or more | 10–20% | — | 55–80% |
30–80% | — | — | 15–25% | |
Pituitary gland tumors | 15–42% | — | — | 30–45% |
Thyroid gland tumors (specifically medullary carcinoma) | — | More than 95% | More than 95% | — |
Pheochromocytoma (tumor of the adrenal glands) | — | 40–50% | 50% | — |
Adrenal cortex tumors | 33% | — | — | — |
Neuromas (growths around nerves) on mucous membranes | — | — | Almost 100% | — |
Physical characteristics similar to those in people with Marfan syndrome | — | — | Almost 100% | — |
10–15% | — | — | 5% | |
Lipomas* | Up to 35% | — | — | — |
Angioma or collagenomas† (especially on the face) | 70–85% | — | — | — |
* A lipoma is a growth of fatty tissue that is usually benign. | ||||
† An angioma is a growth of small blood vessels that is usually benign. A collagenoma is a benign growth of connective tissue in the skin. | ||||
MEN = multiple endocrine neoplasia. | ||||