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Drugs and the Liver

By

Danielle Tholey

, MD, Sidney Kimmel Medical College at Thomas Jefferson University

Last full review/revision Apr 2021| Content last modified Apr 2021
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The body must process (chemically alter, or metabolize) drugs to be able to use and eliminate them. Most of this processing occurs in the liver, done by liver enzymes. Thus, drugs and the liver can affect each other in several ways:

Drugs can affect how quickly certain other drugs are metabolized in the liver. If a drug is metabolized more quickly, it may be broken down and eliminated before it can do what it is supposed to do. In slower drug metabolism Drug Metabolism Drug metabolism is the chemical alteration of a drug by the body. (See also Introduction to Administration and Kinetics of Drugs.) Some drugs are chemically altered by the body (metabolized)... read more , side effects are more likely.

More Information about Drugs and the Liver

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
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Primary Sclerosing Cholangitis
Primary sclerosing cholangitis is inflammation with progressive scarring and narrowing of the bile ducts, both inside and outside the liver. People with which of the following gastrointestinal issues are prone to developing this condition?
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