Furuncles and Carbuncles
(See also Overview of Bacterial Skin Infections.)
Both furuncles and carbuncles may affect healthy young people but are more common among the obese, the immunocompromised (including those with neutrophil defects), the elderly, and possibly those with diabetes. Clustered cases may occur among those living in crowded quarters with relatively poor hygiene or among contacts of patients infected with virulent strains. Predisposing factors include bacterial colonization of skin or nares, hot and humid climates, and occlusion or abnormal follicular anatomy (eg, comedones in acne). Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause.
Furuncles are common on the neck, breasts, face, and buttocks. They are uncomfortable and may be painful when closely attached to underlying structures (eg, on the nose, ear, or fingers). Appearance is a nodule or pustule that discharges necrotic tissue and sanguineous pus.
Carbuncles are clusters of furuncles that are subcutaneously connected. They may be accompanied by fever and prostration.
Abscesses are incised and drained. Intermittent hot compresses are used to facilitate drainage. Antibiotics, when used, should be effective against MRSA, pending culture and sensitivity test results. In afebrile patients, treatment of a single lesion < 5 mm requires no antibiotics. If a single lesion is ≥ 5 mm, an oral antibiotic is given for 5 to 10 days; choices include trimethoprim/sulfamethoxazole (TMP/SMX) 160/800 mg to 320/1600 mg 2 times a day, clindamycin 300 to 600 mg every 6 to 8 hours, and doxycycline or minocycline 100 mg every 12 hours. Patients with fever, multiple abscesses, or carbuncles are given 10 days of TMP/SMX 160/800 mg to 320/1600 mg 2 times a day plus rifampin 300 mg 2 times a day. Systemic antibiotics are also needed for
Lesions > 5 mm or < 5 mm that do not resolve with drainage
Evidence of expanding cellulitis
Patients at risk of endocarditis
Inpatients with furunculosis in hospital settings where MRSA is prevalent may require isolation from other inpatients and be put on any of the following antibiotics:
Furuncles frequently recur and can be prevented by applying liquid soap containing either chlorhexidine gluconate with isopropyl alcohol or 2 to 3% chloroxylenol and by giving maintenance antibiotics over 1 to 2 months. Patients with recurrent furunculosis should be treated for predisposing factors such as obesity, diabetes, occupational or industrial exposure to inciting factors, and nasal carriage of S. aureus or MRSA colonization.
Suspect a furuncle if a nodule or pustule involves a hair follicle and discharges necrotic tissue and sanguineous pus, particularly if on the neck, breasts, face, or buttocks.
Culture furuncles and carbuncles.
Prescribe antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) for patients who are immunocompromised, febrile, or at risk of endocarditis, or if lesions do not resolve with drainage or are > 5 mm, multiple, or expanding.