Деякі лікарські препарати з потенційно серйозними лікарськими взаємодіями*
Mechanism | Examples |
|---|---|
Narrow margin of safety† | Antiarrhythmic drugs (eg, quinidine) Antineoplastic drugs (eg, methotrexate) Digoxin Lithium Theophylline Warfarin |
Extensive metabolism by certain hepatic enzymes | Alprazolam Amitriptyline Atorvastatin Carbamazepine Clozapine Corticosteroids Cyclosporine Diazepam HIV protease inhibitors Imipramine Lovastatin Midazolam Olanzapine Phenytoin Sildenafil Simvastatin Tacrolimus Tadalafil Theophylline Triazolam Vardenafil Warfarin |
Inhibition of certain hepatic enzymes‡ | Aprepitant Boceprevir Cimetidine Ciprofloxacin Clarithromycin Cobicistat Conivaptan Diltiazem Erythromycin Fluconazole Fluoxetine Fluvoxamine Itraconazole Ketoconazole Paroxetine Posaconazole Ritonavir Telaprevir Telithromycin Verapamil Voriconazole |
Induction of certain hepatic enzymes | Barbiturates (eg, phenobarbital) Bosentan Carbamazepine Efavirenz Phenytoin Rifabutin Rifampin St. John’s wort |
* Any medication to be used concurrently with one of these medications should be thoroughly evaluated for possible interactions. † Even when used alone, these medications may have serious adverse effects. Concurrent use of another medication that increases the action of these medications further increases risk of adverse effects. For additional research on potential drug-drug interactions, consult a reliable source, such as the Drugs.com Drug Interaction Checker. ‡ Inhibition also can occur after ingestion of grapefruit products. | |