急性骨髄性白血病でよくみられる細胞遺伝学的異常
細胞遺伝学的異常 | 推定発生率（成人） | 推定発生率（小児） | 予後 |
|---|---|---|---|
t(9;22)/BCR-ABL1；（フィラデルフィア染色体陽性すなわちPh陽性） | 25％ | 5％ | 不良 |
高度の高二倍体（白血病細胞で染色体数が51～65） | 2～11％ | 25％ | 良好 |
低二倍体（白血病細胞で染色体数が46未満） | 5％ | 5％ | 不良 |
t(12;21)/TEL-AML1（ETV6-RUNX1） | < 3％ | 20～25％ | 良好 |
Data from Cytogenetic abnormalities in adult acute lymphoblastic leukemia: correlations with hematologic findings outcome.A Collaborative Study of the Group Français de Cytogénétique Hématologique [published correction appears in Blood 1996 Oct 1;88(7):2818]. Blood 1996;87(8):3135-3142, Fenaux P, Lai JL, Morel P, et al.Cytogenetics and their prognostic value in childhood and adult acute lymphoblastic leukemia (ALL) excluding L3. Hematol Oncol 1989;7(4):307-317.doi:10.1002/hon.2900070409, Pui CH, Crist WM, Look AT.Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 1990;76(8):1449-1463, Bloomfield CD, Secker-Walker LM, Goldman AI, et al.Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia. Cancer Genet Cytogenet 1989;40(2):171-185.doi:10.1016/0165-4608(89)90023-x, Walters R, Kantarjian HM, Keating MJ, et al.The importance of cytogenetic studies in adult acute lymphocytic leukemia. Am J Med 1990;89(5):579-587.doi:10.1016/0002-9343(90)90175-d, and Micallef-Eynaud PD, Eden OB, Grace E, Ellis PM.Cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 1993;10(1):25-30.doi:10.3109/08880019309016524. | |||