Cirrhosis probability in hepatitis C (FIB-4)

 

Input
 

Age		mo yr
Platelets		#/mcL #/microL / nl /mcL /microL /uL 10*3/uL 10*6/uL 10E+9/L 10^3/microL 10e3cells/mcL 10e6 cells/mcL 10e6cells/mcL K/mm3 K/uL Mill/mcl Million/ul Thous/mcL Thousand/uL X10E+09/L X10E+12/L cells/mcL cells/microL cells/uL m/cmm thou/mcL x10(12)/L x10(3)/mcL x10(3)/microL x10(6)/L x10(6)/mcL x10(6)/microL x10(9)/L x1000/mm3 x10^12/L x10^3/mcL x10^3/microL x10^6/L x10^6/mcL x10^6/microL x10^9/L {cells}/uL
ALT		IU/L IntUnit/L U/L Unit/L Units/L mcKat/L
AST		IU/L IntUnit/L U/L Unit/L Units/L mcKat/L

 

Result
 
Important: Inputs must be complete to perform calculation.

 

FIB4 Score		# count index logit none number points score [No Unit]
Decimal Precision   0 1 2 3

 

FIB-4 interpretation

 

Points <1.45:	Cirrhosis less likely
Points >=1.45 and <=3.25:	Indeterminate
Points >3.25:	Cirrhosis more likely

 

 

 

Notes

• FIB-4: fibrosis-4; ALT: alanine aminotransferase; AST: aspartate aminotransferase; INR: international normalized ratio.
• Platelets is the platelet count.
• The FIB-4 index diagnostic cutoffs produce a negative predictive value of 94.7% with sensitivity 73.4% and a positive predictive value of 82.1% with a specificity of 98.2%.

 
Equations used
 

FIB4Score = Age * AST / (Platelets * sqr(ALT))

 

 

References

1. Udell JA, Wang CS, Tinmouth J, et al. Does this patient with liver disease have cirrhosis? JAMA. 2012 Feb 22;307(8):832-42. PubMed ID: 22357834
2. Vallet-Pichard A, Mallet V, Nalpas B, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest. Hepatology. 2007 Jul;46(1):32-6. PubMed ID: 17567829