MSD Manual

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Some Drugs That May Cause an Attack of Acute Intermittent Porphyria*

Some Drugs That May Cause an Attack of Acute Intermittent Porphyria*

Category/Disorder Treated

Examples

Anesthetics (local)

Lidocaine

Antihistamines

Clemastine

Dimenhydrinate

Hydroxyzine

Antiseizure drugs

Barbiturates

Carbamazepine

Ethosuximide

Lamotrigine

Phenytoin

Primidone

Valproate

Certain antihyperglycemic drugs (sulfonylureas)

Chlorpropamide

Glimepiride

Glipizide

Glyburide

Tolbutamide

Antimicrobials

Chloramphenicol

Clindamycin

Erythromycin

Ketoconazole

Nitrofurantoin

Rifampin

Ritonavir

Sulfonamides

Trimethoprim

Heart drugs

Hydralazine

Lidocaine

Methyldopa

Nifedipine

Spironolactone

Hormones

Danazol

Estrogens

Progesterone

Synthetic progestins

Migraine drugs

Dihydroergotamine

Sedatives

Barbiturates

* Because different people with porphyria may react differently to drugs and because many drugs have not been tested in people with porphyria, this list is only for general guidance. People with porphyria should discuss use of any drug, including nonprescription drugs, medicinal herbs, and supplements, with their doctors. The website Porphyria Drugs may provide additional information.