MSD Manual

Please confirm that you are not located inside the Russian Federation

honeypot link
Causes of Thrombocytopenia

Causes of Thrombocytopenia

Mechanism

Examples

Bone marrow does not produce enough platelets

Heavy alcohol consumption

Some bone marrow disorders

Some chemotherapy drugs

Platelets become entrapped in an enlarged spleen

Platelets become diluted

Massive red blood cell replacement or exchange transfusion; stored red blood cells do not contain very many platelets

Use or destruction of platelets increases

Drugs such as heparin, quinine, many antibiotics (such as trimethoprim/sulfamethoxazole, rifampin, and vancomycin), and some oral drugs for diabetes