Table: Polypeptides - MSD Manual Consumer Version

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Polypeptides

Drug	Common Uses	Some Potential Side Effects
Bacitracin Colistin Polymyxin B	Ear, eye, or skin infections Bladder infections (polymyxin B may be used for bladder irrigation) Serious infections caused by susceptible bacteria that are very resistant to many other antibiotics (colistin and polymyxin B given by injection)	Kidney and nerve damage (when given by injection)*
* Polypeptide antibiotics are usually applied directly to the ears, skin, or eyes, but colistin and polymyxin B are sometimes given by injection when bacteria are resistant to all other antibiotics and no safer alternatives are available. Bacitracin is not available for injection.

Drug

Common Uses

Some Potential Side Effects

Bacitracin

Colistin

Polymyxin B

Ear, eye, or skin infections

Bladder infections (polymyxin B may be used for bladder irrigation)

Serious infections caused by susceptible bacteria that are very resistant to many other antibiotics (colistin and polymyxin B given by injection)

Kidney and nerve damage (when given by injection)*

* Polypeptide antibiotics are usually applied directly to the ears, skin, or eyes, but colistin and polymyxin B are sometimes given by injection when bacteria are resistant to all other antibiotics and no safer alternatives are available. Bacitracin is not available for injection.

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