MSD Manual

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Spleen Disorders and Immunodeficiency

By

James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Last full review/revision Apr 2021| Content last modified Apr 2021
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For people whose spleen is absent at birth or has been damaged or removed because of disease, the risk of developing severe bacterial infections is increased.

People who have a spleen disorder or no spleen are given antibiotics at the first sign of infection. Children who do not have a spleen should take antibiotics, usually penicillin or ampicillin, continuously until at least age 5 to prevent an infection in the bloodstream. If they also have an immunodeficiency disorder, they may take these antibiotics indefinitely.

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Angioedema
Angioedema is swelling of tissue under the skin; it sometimes affects the face and throat and often occurs with hives. Which of the following is one way in which angioedema and hives differ?
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