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Effects of Aging on the Liver

By

Christina C. Lindenmeyer

, MD, Cleveland Clinic

Last full review/revision Oct 2019| Content last modified Oct 2019
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The ability of the liver to metabolize many substances decreases with aging. Thus, some drugs are not inactivated as quickly in older people as they are in younger people. As a result, a drug dose that would not have side effects in younger people may have dose-related side effects in older people (see Aging and Drugs Aging and Drugs Drugs, the most common medical intervention, are an important part of medical care for older people. Without drugs, many older people would function less well or die at an earlier age. Older... read more Aging and Drugs ). Thus, drug dosages often need to be decreased in older people. Also, the liver's ability to withstand stress decreases. Thus, substances that are toxic to the liver can cause more damage in older people than in younger people. Repair of damaged liver cells is also slower in older people.

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Primary Sclerosing Cholangitis
Primary sclerosing cholangitis is inflammation with progressive scarring and narrowing of the bile ducts, both inside and outside the liver. People with which of the following gastrointestinal issues are prone to developing this condition?
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