Gas gangrene can develop after certain types of surgery or injuries.
Blisters with gas bubbles form near the infected area, accompanied by fever, rapid heartbeat and breathing, and often pain at the infection site.
Symptoms suggest the diagnosis, and imaging tests or culture of a sample taken from infected tissue is usually done.
Treatment involves high doses of antibiotics and surgical removal of dead or infected tissue.
Gas gangrene is a fast-spreading clostridial infection of muscle tissue that, if untreated, quickly leads to death.
Several thousand cases of gangrene occur in the United States every year.
Clostridia Overview of Clostridial Infections Clostridia are bacteria that commonly reside in the intestine of healthy adults and newborns. Clostridia also reside in animals, soil, and decaying vegetation. These bacteria do not require... read more thrive when no oxygen is present. That is, they are anaerobes Overview of Anaerobic Bacteria Bacteria can be classified in several different ways. One way is based on their need for oxygen—whether they need oxygen to live and grow: Aerobes: Those that need oxygen Anaerobes: Those that... read more . So they reproduce well in soft tissues that have been severely damaged and in wounds that are very deep. Such tissues have poor blood flow and thus low oxygen levels.
Most clostridial soft-tissue infections, including gangrene, are caused by Clostridium perfringens. Clostridial soft-tissue infections usually develop hours or days after an injury but sometimes take several days to appear.
Other clostridial soft-tissue infections include
Shallow skin infections (cellulitis Cellulitis Cellulitis is a spreading bacterial infection of the skin and the tissues immediately beneath the skin. This infection is most often caused by streptococci or staphylococci. Redness, pain, and... read more ), which may not be very painful
Deeper infections into fibrous tissue around the muscles called fascia (fasciitis) or muscle (myositis), which usually are painful
Skin infections rarely spread and become serious.
Sometimes the bacteria in soft tissues produce large amounts of gas as a waste product. The gas can form bubbles and blisters in tissue. Often, the infection blocks small blood vessels. As a result, the infected tissue dies, leading to gangrene. The dead tissue enables the clostridial infection to spread even faster. Gangrene is more likely to develop when muscle is infected than when only the skin is infected.
Gas gangrene usually develops after injuries or surgery. High-risk injuries include wounds that
High-risk surgery includes
Rarely, gas gangrene occurs when there is no injury or surgery—usually in people with colon cancer, diverticulitis, or a disorder that reduces blood flow to the intestine or results in leaks through the wall of the intestine. Gangrene may develop when bacteria that live in the intestine leak out. The bacteria can spread widely.
Gas gangrene causes severe pain in the infected area. Initially, the area is swollen and pale but eventually turns red, then bronze, and finally blackish green. The area is firm and tender to the touch. Large blisters often form. Gas bubbles may be visible within the blister or may be felt under the skin, usually after the infection progresses. Fluids draining from the wound smell rotten (putrid).
People quickly become feverish, sweaty, and very anxious. They may vomit. Heart rate and breathing often become rapid. In some people, the skin turns yellow, indicating jaundice Jaundice in Adults In jaundice, the skin and whites of the eyes look yellow. Jaundice occurs when there is too much bilirubin (a yellow pigment) in the blood—a condition called hyperbilirubinemia. (See also Overview... read more . These effects are caused by toxins produced by the bacteria.
Typically, people remain alert until late in the illness, when dangerously low blood pressure (shock Shock Shock is a life-threatening condition in which blood flow to the organs is low, decreasing delivery of oxygen and thus causing organ damage and sometimes death. Blood pressure is usually low... read more ) and coma develop. Kidney failure and death rapidly follow.
Without treatment, death occurs in 100% of infected people, usually within 48 hours. Even with treatment, about one in four people die.
Gas gangrene is suspected based on symptoms and results of a physical examination.
X-rays are taken to check for gas bubbles in muscle tissue, or computed tomography (CT) or magnetic resonance imaging (MRI) is done to check for areas of dead muscle tissue. These findings support the diagnosis. However, gas bubbles may also occur in other anaerobic infections.
Fluids from the wound are examined under a microscope to check for clostridia and are sent to a laboratory where bacteria, if present, can be grown (cultured) and tested. Cultures can confirm the presence of clostridia. However, not all people with clostridia have gas gangrene.
Confirmation of the diagnosis often requires exploratory surgery or removal of a tissue sample for examination under a microscope (biopsy) to check for characteristic changes in muscle.
If gas gangrene is suspected, treatment must begin immediately.
High doses of antibiotics, typically penicillin and clindamycin, are given, and all dead and infected tissue is removed surgically. About one of five people with gas gangrene in a limb requires amputation.
Treatment in a high-pressure oxygen (hyperbaric oxygen) chamber may also be helpful, but such chambers are not always readily available.