(See also Overview of Transplantation Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. The most common type of... read more .)
Skin grafts can be used in people who have lost large areas of skin—for example, because of extensive burns Burns Burns are injuries to tissue that result from heat, electricity, radiation, or chemicals. Burns cause varying degrees of pain, blisters, swelling, and skin loss. Small, shallow burns may need... read more . Skin grafting is most successful when healthy skin is removed from one part of the body and grafted to another part. When such grafting is not possible, skin from a donor or even from animals (such as pigs) or synthetic skin can be used as a temporary measure. Such grafts last only a short time, but they can provide temporary protection until normal skin grows to replace them.
The amount of skin available for grafting may be increased by growing small pieces of the person’s skin in a tissue culture or by making many tiny cuts in the grafted skin, so that it can be stretched to cover a much larger area.
Cartilage is usually used to repair birth defects in the ears Ear Defects Ears can be missing, deformed, or incompletely developed at birth. (See also Introduction to Birth Defects of the Face, Bones, Joints, and Muscles.) Birth defects of the ear include the following... read more or nose of children. In adults, it can be used to repair joints damaged by injury or by arthritis.
Cartilage may be transplanted successfully without the use of drugs to suppress the immune system (immunosuppressants Suppression of the Immune System Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. The most common type of... read more ). The body’s immune system attacks transplanted cartilage much less vigorously than other tissues.
Corneas Corneal Transplantation Corneal transplantation (keratoplasty) is a common and highly successful type of transplantation. A scarred, severely painful, perforated, misshapen, or cloudy cornea (the clear layer in front... read more , the transparent domes on the surface of the eyes, can usually be transplanted successfully without the use of immunosuppressants.
Bone from one part of the body can be used to replace bone in another part—for example, to replace bone removed during surgery for bone cancer.
Bone transplanted from one person to another survives only a short time. However, it stimulates growth of new bone, stabilizes the area until new bone can form, and provides a framework for new bone to fill in.
Immunosuppressants are not needed after bone transplantation.
Some transplants contain more than one tissue (called composite transplants, such as hand, arm, or face transplants). Composite transplants may include skin, muscle, bone, and tissues that connect and support these structures.
Composite transplantation is controversial because it typically is not needed to preserve life and does not extend it, although it may greatly improve quality of life. Composite transplantation is also very expensive, requires many resources, and may result in sometimes life-threatening infections. These procedures are not considered standard medical care.
How well the transplanted parts function varies widely, but some recipients of a hand transplant are able to use the hand to do their usual daily activities.
In Parkinson disease, transplanting tissue from a person’s adrenal glands to that person’s brain appears to relieve symptoms, as does transplanting brain tissue from aborted fetuses. However, use of tissue from aborted fetuses is controversial.
Transplantation of thymus glands from stillborn infants into children who are born without a thymus gland (a disorder called DiGeorge syndrome DiGeorge Syndrome DiGeorge syndrome is a congenital immunodeficiency disorder in which the thymus gland is absent or underdeveloped at birth. Children with DiGeorge syndrome are born with several abnormalities... read more ) may help restore the immune system in these children. When the thymus gland is missing, the immune system is impaired because white blood cells, which are a vital part of the immune system’s defense against foreign substances, mature in the thymus gland. However, the new thymus may produce cells that attack the recipient’s cells, causing severe graft-versus-host disease Graft-versus-host disease Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. The most common type of... read more .