MSD Manual

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Common Causes of Anemia

Common Causes of Anemia



Chronic excessive bleeding

Cancer in the digestive tract

Ulcers in the stomach or small intestine

Sudden excessive bleeding


A ruptured blood vessel


Decreased red blood cell production

Metastatic cancer

Myelodysplasia (abnormalities in bone marrow tissue)

Increased red blood cell destruction

Autoimmune reactions against red blood cells

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Hereditary elliptocytosis

Hereditary spherocytosis

Hereditary stomatocytosis

Hereditary xerocytosis

Mechanical damage to red blood cells

Paroxysmal nocturnal hemoglobinuria