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Asbestos-Related Pleural Disease


Abigail R. Lara

, MD, University of Colorado

Last full review/revision May 2020| Content last modified May 2020
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Asbestos is a family of naturally occurring compounds whose heat-resistant and structural properties made it useful for inclusion in construction and shipbuilding materials, automobile brakes, and some textiles. Asbestos can be found in low levels in the air, water, and soil, but this low level of environmental exposure is not a significant contributor to human disease. Asbestos is composed of fibrous mineral silicates of different chemical compositions. When inhaled, asbestos fibers settle deep in the lungs, causing scars. Asbestos inhalation also can cause the two layers of membranes covering the lungs (the pleura) to thicken. These thickenings are called pleural plaques. These plaques do not become cancerous.

Inhaling asbestos fibers can occasionally cause fluid to accumulate in the space between the two pleural layers of the lungs (pleural space). This fluid accumulation is called a noncancerous (benign) asbestos effusion.

People with a noncancerous asbestos effusion may have difficulty breathing because of fluid accumulation. Pleural plaques tend to cause only mild breathing difficulty resulting from stiffness of the chest wall. Sometimes plaques cause no symptoms but decrease lung function.

Diagnosis of Asbestos-Related Pleural Disease

  • A history of asbestos exposure

  • Chest imaging

Pleural plaques that develop in many people with exposure to asbestos often contain calcium, which makes them easy to see on chest x-rays and computed tomography (CT).

If a tumor of the pleura is found on the x-ray, CT is usually done. If CT confirms that a tumor is possible, doctors must do a biopsy (remove a small piece of pleura and examine it under a microscope) to determine whether the tumor is cancerous. Fluid around the lungs may be removed with a needle and analyzed for cancer cells (a procedure called thoracentesis Thoracentesis Thoracentesis is the placement of a needle through the skin into the chest cavity to withdraw a sample of fluid. In thoracentesis, fluid that has collected abnormally in the pleural space (termed... read more ). However, thoracentesis is not usually as accurate as a pleural biopsy.

Treatment of Asbestos-Related Pleural Disease

  • Treatment to relieve symptoms

Symptoms are treated as necessary. Occasionally, doctors need to drain fluid by inserting a tube into the chest.

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Goodpasture Syndrome
Goodpasture syndrome is an uncommon autoimmune disorder in which bleeding into the lungs and progressive kidney failure occur. People with the syndrome usually have difficulty breathing and cough up blood. Which of the following groups is most likely to developing Goodpasture syndrome?
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