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MSD Manual

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Drug-Induced Autoimmune Endocrine Disorders


Jennifer M. Barker

, MD, Children's Hospital Colorado, Division of Pediatric Endocrinology

Last full review/revision Jun 2019| Content last modified Jun 2019
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People receiving cancer therapy drugs called immune checkpoint inhibitors have an increased risk for developing autoimmune disorders, including endocrine disorders. Inflammation of the pituitary gland (hypophysitis), autoimmune thyroid disease, type 1 diabetes mellitus, and underactive adrenal glands have occurred.

Doctors measure the levels of hormones in the blood.

Treatment involves replacing the hormones documented to be deficient. These might include thyroid hormone, insulin, or glucocorticoids.

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