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ZAP-70 Deficiency

By

James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Medically Reviewed Jan 2023
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ZAP-70 (zeta-associated protein 70) deficiency is a genetic disorder of the immune system that results in an abnormality in T cells that prevents T cells from becoming activated to fight specific infections.

ZAP-70 deficiency causes recurrent infections similar to those in severe combined immunodeficiency Severe Combined Immunodeficiency (SCID) Severe combined immunodeficiency is a primary immunodeficiency disorder resulting in low levels of antibodies (immunoglobulins) and low or no T cells (lymphocytes). Most infants with severe... read more (SCID) in infants and young children. However, the deficiency may not be diagnosed until children are several years old.

More Information

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
VIEW PROFESSIONAL VERSION
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