MSD Manual

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Spleen Disorders and Immunodeficiency

By

James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Medically Reviewed Apr 2021 | Modified Sep 2022
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For people whose spleen is absent at birth or has been damaged or removed because of disease, the risk of developing severe bacterial infections is increased.

People who have a spleen disorder or no spleen are given antibiotics at the first sign of infection. Children who do not have a spleen should take antibiotics, usually penicillin or ampicillin, continuously until at least age 5 to prevent an infection in the bloodstream. If they also have an immunodeficiency disorder, they may take these antibiotics indefinitely.

NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
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