MSD Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Unexplained Infertility

By

Robert W. Rebar

, MD, Western Michigan University Homer Stryker M.D. School of Medicine

Medically Reviewed Oct 2022
VIEW PROFESSIONAL VERSION

Unexplained infertility is diagnosed when sperm in the man is normal, when eggs, ovulation, fallopian tubes, and the uterus are normal in the woman, and when no other reason for infertility is identified.

Treatment of Unexplained Infertility

  • Controlled ovarian stimulation

  • Sometimes assisted reproductive technologies

When no explanation for infertility is identified, an approach called controlled ovarian stimulation may be used.

Controlled ovarian stimulation may make pregnancy more likely and may help women become pregnant more quickly. This treatment may result in more than one fetus.

Controlled ovarian stimulation involves the following:

If pregnancy does not result after this treatment, one of the following may be done:

Prognosis for Unexplained Infertility

Women have the same chance of pregnancy (about 65%) whether unsuccessful treatment with clomiphene plus hCG is followed by stimulation with gonadotropins plus hCG or immediately by in vitro fertilization. However, women become pregnant more quickly and are less likely to have a pregnancy with three or more fetuses when unsuccessful treatment with clomiphene is immediately followed by in vitro fertilization. Thus, if clomiphene plus intrauterine insemination is unsuccessful, the next step is often in vitro fertilization.

Some evidence suggests that women who are over 38 and have unexplained infertility conceive more quickly when in vitro fertilization is done before controlled ovarian stimulation is tried.

NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
VIEW PROFESSIONAL VERSION
quiz link

Test your knowledge

Take a Quiz! 
iOS ANDROID
iOS ANDROID
iOS ANDROID
TOP