S-adenosyl-L-methionine (SAMe) is a naturally occurring agent in the human body, produced largely by the liver. It is also manufactured synthetically as a supplement. (See also Overview of Dietary Supplements Overview of Dietary Supplements Integrative medicine and health (IMH) and complementary and alternative medicine (CAM) include healing approaches and therapies that historically have not been included in conventional, mainstream... read more .)
SAMe is said to be effective in treating depression, osteoarthritis, gallbladder, and liver disorders, but scientific studies so far do not clearly confirm these claims. More research is needed to verify its effectiveness for depression, but it may help people who have osteoarthritis function better. Better studies are needed to evaluate whether SAMe helps people with liver disorders.
Possible side effects
No serious side effects have been reported. People with a bipolar disorder should not use SAMe because it can cause manic episodes.
Possible drug interactions
Combining antidepressant drugs with SAMe, both of which will increase serotonin levels, may cause adverse effects such as rapid heart rate and anxiety.
More Information about SAMe
The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
National Institutes of Health (NIH), National Center for Complementary and Integrative Health: Information on research regarding the use of SAMe for depression, osteoarthritis, and liver diseases