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Quick Facts

Guillain-Barré Syndrome (GBS)

(Acute Inflammatory Demyelinating Polyneuropathy; Acute Idiopathic Polyneuritis)


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Last full review/revision Jul 2020| Content last modified Jul 2020
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What is GBS?

Guillain-Barré syndrome (GBS) is muscle weakness that happens over a few days or a few weeks.

  • GBS is probably caused by an autoimmune reaction (when your body's immune system attacks parts of your own body)

  • It's often triggered by a minor infection

  • Usually, weakness and abnormal sensations begin in both legs and move up your body

  • A few people get so weak they have trouble breathing

  • Doctors put you in the hospital and give you medicine to slow down your immune system

  • It usually gets better on its own in a few months, but some people are weak for a long time

What causes GBS?

Most people get GBS several days to a few weeks after having:

  • A minor illness such as stomach flu or a cold

  • Surgery

Doctors think that you get GBS when your immune system attacks your nerves so they can’t send messages normally. GBS mainly attacks nerves that control muscle movement and sensation. Rarely, it attacks nerves that control your blood pressure and your heart and other organs.

What are the symptoms of GBS?

Symptoms include:

  • Weakness or pins-and-needles feeling that starts in your legs and moves upward

  • Trouble feeling things (loss of sensation)

  • Sometimes, trouble breathing, chewing, swallowing, or speaking

Weakness caused by GBS usually gets worse over 3 to 4 weeks, then remains the same or starts to get better.

In severe cases, symptoms may include:

  • Blood pressure problems

  • Abnormal heart rhythm

  • Not being able to urinate (pee)

  • Constipation (trouble passing stool)

How can doctors tell if I have GBS?

Doctors do tests to diagnose GBS, such as:

  • Electromyography (a muscle test that uses small needles to record the electrical activity of your muscles)

  • Spinal tap (doctors use a long needle to get spinal fluid from your lower back)

How do doctors treat GBS?

Doctors will care for you in the hospital because you may develop life-threatening breathing problems very quickly. Treatment should start as soon as possible. It may include:

  • Immune globulin given by vein (medicine that contains helpful antibodies that can block antibodies that are damaging your nerves)

  • Plasma exchange (a process that filters your blood to take out the antibodies attacking your nerves)

If your breathing gets weak, doctors may:

  • Put a tube down your throat into your lungs and attach it to a breathing machine (ventilator)

It may take a long time to recover from GBS. Most people recover within a year, but some people take longer and never completely gain back their muscle strength.

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Anosmia is the total loss of smell. Most people with anosmia can taste sweet, sour, salty, and bitter substances but cannot distinguish among specific flavors. This is because the sense of smell makes it possible to distinguish among flavors, not taste receptors as many people erroneously believe. Which of the following is NOT a common cause of anosmia?
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