Not Found
Locations

Find information on medical topics, symptoms, drugs, procedures, news and more, written for the health care professional.

* This is the Professional Version. *

Marchiafava-Bignami Disease

By Gerald F. O’Malley, DO, Thomas Jefferson University and Hospital ; Rika O’Malley, MD, Einstein Medical Center

Click here for
Patient Education

Marchiafava-Bignami disease is a rare demyelination of the corpus callosum that occurs in chronic alcoholics, predominantly men.

Pathology and circumstances link this disorder to osmotic demyelination syndrome (previously called central pontine myelinolysis), of which it may be a variant. In Marchiafava-Bignami disease, the speed of onset and the degree of physical findings vary.

Patients can present with acute, subacute, or chronic onset of mental status change varying from lethargy to coma, seizure, ocular movement dysfunction, memory loss, and gait disturbance.

Some patients recover over several months. Patients who present in coma and stupor have a mortality rate of about 20%.

There is no specific treatment, but supportive care typically includes vitamin supplementation (particularly of thiamin, folate, and other B vitamins) and correction of malnutrition.

* This is the Professional Version. *