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Lincosamides, Oxazolidinones, and Streptogramins

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Lincosamides (clindamycin—see Clindamycin ), oxazolidinones (linezolid, tedizolid—see Linezolid and Tedizolid ), and streptogramins (dalfopristin [streptogramin A] and quinupristin [streptogramin B]—see Quinupristin and Dalfopristin ) are grouped together because they have a similar mode of antibacterial action and similar antibacterial spectra. Macrolides (see Macrolides ) and the ketolide telithromycin (see Telithromycin ) may be included with this group for similar reasons. All inhibit protein synthesis by binding to the 50S ribosomal subunit.

Cross-resistance occurs among the following antibiotics because they bind to the same target:

  • Macrolides

  • Clindamycin

  • Quinupristin

  • Telithromycin (to some extent)

However, cross-resistance does not occur between these antibiotics and dalfopristin and linezolid, which bind to different targets on the 50S ribosomal subunit.

* This is the Professional Version. *